Denver, Colo. (May 1, 2011) — A drug commonly used to treat kidney cancer may increase the effectiveness of chemotherapy for mesothelioma, according to a study published in the May issue of the Journal of Thoracic Oncology.
Temsirolimus, a kinase inhibitor, blocks the action of mammalian target of rapamycin (mTOR), a protein that regulates cell growth, which can slow tumor growth. It’s used to treat advanced renal cell carcinoma.
But researchers in Austria have found that temsirolimus also may slow the growth of malignant pleural mesothelioma cells. Mesothelioma, a cancer that is usually caused by exposure to asbestos and may not appear until 30 to 50 years after exposure, frequently resists chemotherapy and radiation treatment.
The researchers found that temsirolimus strongly blocked mTOR-mediated signals and had a cytostatic, or growth-stopping, effect on all mesothelioma cells. However, mesothelioma cells that were resistant to cisplatin, a widely used chemotherapy drug, showed hypersensitivity against temsirolimus.
That suggests that mTOR inhibitors like temsirolimus might be a promising treatment strategy either in combination with chemotherapy or as second-line treatment after chemotherapy failure.
“Malignant mesothelioma is a severe human malignancy characterized by a very bad prognosis, with a mean patient survival time of less than one year,” said Professor Walter Berger, PhD, of the Institute of Cancer Research at the Medical University of Vienna. “This unacceptable situation is mainly caused by late diagnosis combined with a distinct resistance to all forms of systemic therapy available so far. Mesothelioma is frequently caused by asbestos exposure and unfortunately — based on the long latency period — the incidence peak lies, despite the ban on asbestos, still ahead. Consequently, novel therapeutic options for this devastative disease are urgently needed.
“In our preclinical study, published in the JTO, we were able to demonstrate that inhibition of the major oncogene mTOR is active against human mesothelioma especially after development of chemotherapy resistance both in vitro and in vivo,” Berger said. “These results suggest the initiation of clinical trials involving mTOR inhibitors as a novel anti-mesothelioma strategy.”
renal cell carcinoma wikipedia the free encyclopedia Renal cell carcinoma (RCC, also known as hypernephroma) is a kidney cancer that originates in the lining of the proximal convoluted tubule, the very small tubes in .
national institute for health and clinical excellence NICE sets standards for quality healthcare and produces guidance on medicines, treaments and procedures..
san diego health directory utimate directory to know all about ur San Diego Health care, physician directory, medical care, nutrition, supplements..
sciencedaily mesothelioma news science daily news amp; articles Read the medical research on mesothelioma including mesothelioma symptoms and treatments. Information on mesothelioma and asbestos..
riditt Actos Bladder Cancer Lawsuits: The incidence of bladder cancer has risen over the past 20 years. Currently, around 54 500 new cases of bladder cancer are diagnosed in .
daily cancer news cancerconnect news Daily Cancer News. CancerConsultants provides summaries of new treatment strategies as they are discovered and reported by cancer physicians around the world..
medical news today health news Medical news and health news headlines posted throughout the day, every day.
health Welcome to mesothelioma-picture.com is blog personal. Here is home on page 0 , Surprise discovery of unknown breast cancer genes could revolutionise treatment .
comprehensive cancer information national cancer institute Accurate, up-to-date, comprehensive cancer information from the U.S. government's principal agency for cancer research..
cancer care blog easy to treat cancer easy to treat cancer Cell-CT: A new dimension in breast cancer research. ScienceDaily (Jan. 5, 2012) — Despite advances in both the diagnosis and treatment of .